Which CYP450 polymorphism is most relevant for the activation of the antiplatelet drug Clopidogrel?
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Correct answer: CYP2C19
Clopidogrel is a prodrug that requires a two-step activation process, where CYP2C19 plays a critical role. 'Loss-of-function' carriers (e.g., *2 or *3 alleles) have reduced active metabolite levels and a higher risk of cardiovascular events.
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