Cholinergic Agonists · Pharmacology

Which indirect-acting cholinergic agonist is often used to reverse the effects of non-depolarizing neuromuscular blockers like Rocuronium after surgery?

  1. Neostigmine
  2. Succinylcholine
  3. Pancuronium
  4. Bethanechol
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Correct answer: Neostigmine

Neostigmine inhibits acetylcholinesterase at the neuromuscular junction, increasing the concentration of acetylcholine. This allows acetylcholine to compete with and displace the non-depolarizing blocker from the nicotinic receptors.

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