Cholinergic Agonists · Pharmacology

Which of the following describes the effect of muscarinic agonists on the gastrointestinal tract?

  1. Decreased peristalsis and sphincter contraction
  2. Increased peristalsis and sphincter relaxation
  3. Increased peristalsis and sphincter contraction
  4. No significant effect on GI motility
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Correct answer: Increased peristalsis and sphincter relaxation

Parasympathetic stimulation ('rest and digest') enhances GI activity. Muscarinic agonists increase the tone and motility of the gut while relaxing sphincters to facilitate the passage of contents.

Difficulty: Medium Question 17 of 20

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