Cholinergic Agonists · Pharmacology

Carbachol is used in the eye to produce miosis. How does it differ from Pilocarpine?

  1. It acts only indirectly by releasing acetylcholine
  2. It has both muscarinic and significant nicotinic activity
  3. It is a pure nicotinic receptor antagonist
  4. It is hydrolysed by acetylcholinesterase much more rapidly
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Correct answer: It has both muscarinic and significant nicotinic activity

Carbachol is a potent choline ester that acts as a direct agonist at both muscarinic and nicotinic receptors. It is resistant to acetylcholinesterase and can also trigger the release of acetylcholine from nerve terminals.

Difficulty: Medium Question 19 of 20

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