Cholinergic Agonists · Pharmacology

A patient with non-obstructive urinary retention is prescribed Bethanechol. What is the expected physiological effect on the bladder?

  1. Relaxation of the detrusor muscle and contraction of the trigone
  2. Contraction of the detrusor muscle and relaxation of the trigone
  3. Relaxation of both the detrusor and the trigone muscles
  4. Contraction of both the detrusor and the trigone muscles
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Correct answer: Contraction of the detrusor muscle and relaxation of the trigone

Muscarinic stimulation by Bethanechol causes the detrusor muscle to contract and the internal urethral sphincter (trigone) to relax. This coordinated action facilitates bladder emptying in patients with atony.

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