Beta-Lactam Antibiotics · Pharmacology

Which of the following beta-lactamase inhibitors is commonly paired with Piperacillin to extend its spectrum of activity?

  1. Clavulanic acid
  2. Sulbactam
  3. Tazobactam
  4. Avibactam
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Correct answer: Tazobactam

Tazobactam is a suicide inhibitor of bacterial beta-lactamases. When combined with Piperacillin (Zosyn), it protects the antibiotic from degradation, allowing it to target resistant Gram-negative organisms including Pseudomonas.

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