A patient with a history of immediate hypersensitivity (anaphylaxis) to Penicillin G should generally avoid which of the following classes due to a potential risk of cross-reactivity?
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Correct answer: First-generation cephalosporins
First-generation cephalosporins, such as Cephalexin, share similar side chains with penicillins, increasing the risk of cross-reactivity. In patients with documented penicillin anaphylaxis, cephalosporins should be avoided or used with extreme caution.
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