Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to most beta-lactams because it possesses an altered PBP known as:
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Correct answer: PBP2a
MRSA acquires the mecA gene, which encodes PBP2a. This altered protein has a very low affinity for almost all beta-lactam antibiotics, rendering them ineffective at inhibiting cell wall synthesis.
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