Which of the following is a 'carbapenem' antibiotic that is always administered with Cilastatin to prevent renal degradation?
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Correct answer: Imipenem
Imipenem is rapidly inactivated by the enzyme dehydropeptidase I in the renal tubules. Cilastatin is a dehydropeptidase inhibitor that prevents this breakdown, increasing the drug's concentration and preventing potential nephrotoxicity.
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