Which of the following is a Monobactam antibiotic that is safe to use in patients with a penicillin allergy and targets only Gram-negative bacteria?
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Correct answer: Aztreonam
Aztreonam has a unique monocyclic beta-lactam ring that does not cross-react with other beta-lactams (except possibly Ceftazidime). It is highly specific for aerobic Gram-negative rods and has no activity against Gram-positive or anaerobic organisms.
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