Beta-Lactam Antibiotics · Pharmacology

Which specific penicillin is considered the drug of choice for treating syphilis (Treponema pallidum)?

  1. Amoxicillin with clavulanate
  2. Penicillin V Potassium
  3. Penicillin G Benzathine
  4. Dicloxacillin sodium
Show answer and explanation

Correct answer: Penicillin G Benzathine

Penicillin G Benzathine is an intramuscular, long-acting depot formulation. Treponema pallidum remains highly sensitive to penicillin, and this formulation maintains therapeutic levels for weeks, which is necessary for eradication.

Difficulty: Medium Question 5 of 20

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