Which specific area of the brain is typically the first to show neurofibrillary tangles in the earliest stages of Alzheimer disease?
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Correct answer: Entorhinal cortex
According to Braak staging, neurofibrillary tangles typically appear first in the entorhinal cortex and hippocampus before spreading to other neocortical areas. This correlates with early short-term memory deficits.
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