The loss of which neurotransmitter system is most prominently linked to the cognitive decline in Alzheimer disease?
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Correct answer: Cholinergic system, specifically in the Nucleus Basalis of Meynert
The 'cholinergic hypothesis' highlights the profound loss of acetylcholine-producing neurons in the Nucleus Basalis of Meynert. This deficiency is the target of current symptomatic treatments like acetylcholinesterase inhibitors.
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