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Neuropathology

Alzheimer Disease Practice Questions

20 free Alzheimer Disease practice questions for the Pathology, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.

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All Alzheimer Disease questions

20 questions
  1. Q1. Which of the following is the primary protein component of the extracellular neuritic plaques found in Alzheimer disease?
  2. Q2. In Alzheimer disease, neurofibrillary tangles (NFTs) are composed of which of the following proteins?
  3. Q3. Which enzyme is responsible for the initial 'non-amyloidogenic' cleavage of Amyloid Precursor Protein (APP), preventing the formation of Amyloid-beta?
  4. Q4. Which genetic risk factor is most strongly associated with the sporadic (late-onset) form of Alzheimer disease?
  5. Q5. A 45-year-old patient with Down Syndrome (Trisomy 21) is at high risk for early-onset Alzheimer disease because the gene for which protein is located on chromo…
  6. Q6. Which macroscopic brain change is most characteristic of advanced Alzheimer disease?
  7. Q7. Which of the following describes the 'amyloid cascade hypothesis' of Alzheimer disease?
  8. Q8. Which specific area of the brain is typically the first to show neurofibrillary tangles in the earliest stages of Alzheimer disease?
  9. Q9. What is the function of the gamma-secretase complex in the pathogenesis of Alzheimer disease?
  10. Q10. Which of the following pathological features of Alzheimer disease is best visualized using a Silver (Bielschowsky) stain?
  11. Q11. Cerebral Amyloid Angiopathy (CAA), often associated with Alzheimer disease, involves the deposition of Aβ in which location?
  12. Q12. What are 'Hirano bodies,' which are frequently observed in the hippocampus of Alzheimer patients?
  13. Q13. The loss of which neurotransmitter system is most prominently linked to the cognitive decline in Alzheimer disease?
  14. Q14. Which of the following mutations is the most common cause of early-onset familial Alzheimer disease?
  15. Q15. Granulovacuolar degeneration is a histological change characterized by clear vacuoles containing a central granule, primarily found in which cells?
  16. Q16. In the context of AD, what is 'hydrocephalus ex vacuo'?
  17. Q17. Which form of Amyloid-beta is considered the most neurotoxic and prone to aggregation?
  18. Q18. Which of the following statements regarding the correlation between AD pathology and clinical symptoms is correct?
  19. Q19. Apolipoprotein E (APOE) is primarily involved in the transport of which substance in the central nervous system?
  20. Q20. Which of the following is an established biomarker found in the cerebrospinal fluid (CSF) of patients with Alzheimer disease?