What is the function of the gamma-secretase complex in the pathogenesis of Alzheimer disease?
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Correct answer: It performs the final intramembrane cleavage of APP to release Aβ
Gamma-secretase is a multi-protein complex (including Presenilin) that cleaves the C-terminal fragment of APP within the cell membrane. This step is required to release the Amyloid-beta peptide.
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