Which enzyme is responsible for the initial 'non-amyloidogenic' cleavage of Amyloid Precursor Protein (APP), preventing the formation of Amyloid-beta?
Show answer and explanation
Correct answer: Alpha-secretase
Alpha-secretase cleaves APP within the Aβ domain, which precludes the formation of the toxic Aβ peptide. This is known as the non-amyloidogenic pathway.
Keep practicing
More Alzheimer Disease questions
- Which genetic risk factor is most strongly associated with the sporadic (late-onset) form of Alzheimer disease?
- A 45-year-old patient with Down Syndrome (Trisomy 21) is at high risk for early-onset Alzheimer disease because the gene for which protein…
- Which macroscopic brain change is most characteristic of advanced Alzheimer disease?
- Which of the following describes the 'amyloid cascade hypothesis' of Alzheimer disease?
- Which specific area of the brain is typically the first to show neurofibrillary tangles in the earliest stages of Alzheimer disease?
- What is the function of the gamma-secretase complex in the pathogenesis of Alzheimer disease?