In Alzheimer disease, neurofibrillary tangles (NFTs) are composed of which of the following proteins?
Show answer and explanation
Correct answer: Hyperphosphorylated tau protein
Neurofibrillary tangles are intracellular inclusions consisting of paired helical filaments. These filaments are made of tau protein that has been abnormally hyperphosphorylated, leading to microtubule instability.
Keep practicing
More Alzheimer Disease questions
- Which enzyme is responsible for the initial 'non-amyloidogenic' cleavage of Amyloid Precursor Protein (APP), preventing the formation of Am…
- Which genetic risk factor is most strongly associated with the sporadic (late-onset) form of Alzheimer disease?
- A 45-year-old patient with Down Syndrome (Trisomy 21) is at high risk for early-onset Alzheimer disease because the gene for which protein…
- Which macroscopic brain change is most characteristic of advanced Alzheimer disease?
- Which of the following describes the 'amyloid cascade hypothesis' of Alzheimer disease?
- Which specific area of the brain is typically the first to show neurofibrillary tangles in the earliest stages of Alzheimer disease?