A 45-year-old patient with Down Syndrome (Trisomy 21) is at high risk for early-onset Alzheimer disease because the gene for which protein is located on chromosome 21?
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Correct answer: Amyloid Precursor Protein (APP)
The APP gene is located on chromosome 21. Individuals with Down Syndrome have three copies of the gene, leading to increased production of Amyloid-beta and the development of AD pathology often by the age of 40.
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