What is the role of 'Angiogenesis' in tumor growth?
Show answer and explanation
Correct answer: It is the recruitment of new blood vessels to supply the tumor with nutrients and oxygen
Solid tumors cannot grow beyond 1-2 mm in diameter without a blood supply. They trigger an 'angiogenic switch' by secreting factors like VEGF to stimulate the growth of new vessels from the existing host vasculature.
Keep practicing
More Carcinogenesis questions
- Which of the following describes the 'Initiation' stage of chemical carcinogenesis?
- The 'Two-Hit Hypothesis' by Knudson is most famously associated with the development of which tumor?
- Which of the following is considered a 'Direct-acting' chemical carcinogen?
- In the context of oncogenes, what is the effect of a 'point mutation' in the RAS gene?
- What is the primary mechanism by which the p53 protein prevents carcinogenesis following DNA damage?
- The translocation t(8;14) resulting in the overexpression of the MYC proto-oncogene is the molecular hallmark of: