The 'Two-Hit Hypothesis' by Knudson is most famously associated with the development of which tumor?
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Correct answer: Retinoblastoma
Knudson's hypothesis states that both alleles of a tumor suppressor gene (like RB1) must be inactivated to trigger cancer. In hereditary retinoblastoma, the first 'hit' is inherited, while the second occurs somatically.
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