The translocation t(8;14) resulting in the overexpression of the MYC proto-oncogene is the molecular hallmark of:
Show answer and explanation
Correct answer: Burkitt lymphoma
In Burkitt lymphoma, the MYC gene on chromosome 8 is moved to the immunoglobulin heavy chain locus on chromosome 14. This leads to the constitutive high-level expression of the MYC transcription factor, driving rapid cell proliferation.
Keep practicing
More Carcinogenesis questions
- Which of the following describes the role of 'Promoters' in chemical carcinogenesis?
- Which oncogenic virus is strongly associated with the development of Kaposi sarcoma in immunocompromised patients?
- How do the E6 and E7 oncoproteins of High-risk HPV (Types 16 and 18) contribute to carcinogenesis?
- Which of the following is a classic example of 'Tumor Progression'?
- In the Hallmarks of Cancer, 'Limitless Replicative Potential' is primarily achieved through:
- What is the function of the APC (Adenomatous Polyposis Coli) gene in the WNT signaling pathway?