Which DNA repair deficiency is associated with a high risk of skin cancer due to the inability to repair UV-induced damage?
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Correct answer: Xeroderma Pigmentosum
Xeroderma Pigmentosum is an autosomal recessive disorder caused by mutations in the Nucleotide Excision Repair (NER) genes. Affected individuals cannot repair pyrimidine dimers caused by UV light, leading to skin cancers at a very young age.
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