Which of the following describes the 'Initiation' stage of chemical carcinogenesis?
Show answer and explanation
Correct answer: Rapid and irreversible induction of a DNA mutation
Initiation is the first step of carcinogenesis, involving exposure of cells to a sufficient dose of a carcinogenic agent. It results in permanent DNA damage that is rapid and irreversible, though not yet sufficient for tumor formation on its own.
Keep practicing
More Carcinogenesis questions
- The 'Two-Hit Hypothesis' by Knudson is most famously associated with the development of which tumor?
- Which of the following is considered a 'Direct-acting' chemical carcinogen?
- In the context of oncogenes, what is the effect of a 'point mutation' in the RAS gene?
- What is the primary mechanism by which the p53 protein prevents carcinogenesis following DNA damage?
- The translocation t(8;14) resulting in the overexpression of the MYC proto-oncogene is the molecular hallmark of:
- Which of the following describes the role of 'Promoters' in chemical carcinogenesis?