What is the primary pathological mechanism in Myasthenia Gravis?
Show answer and explanation
Correct answer: Antibody-mediated blockade of synaptic ACh receptors
Myasthenia Gravis is a Type II hypersensitivity disorder where autoantibodies bind to post-synaptic acetylcholine receptors. This leads to receptor internalization and impaired neuromuscular transmission, causing muscle weakness.
Keep practicing
More Autoimmune Diseases questions
- In Sjogren syndrome, the immune-mediated destruction primarily targets which of the following tissues?
- Which histological feature is characteristic of the 'Libman-Sacks' endocarditis seen in SLE?
- Systemic Sclerosis (Scleroderma) is characterized by excessive fibrosis. Which cytokine is considered a major mediator of this fibrotic res…
- Which of the following is a component of the CREST syndrome variant of Limited Scleroderma?
- Patients with which of the following HLA alleles have a significantly higher risk of developing Ankylosing Spondylitis?
- What is the characteristic histological finding in the joints of a patient with Rheumatoid Arthritis?