Autoimmune Diseases · Pathology

What is the characteristic histological finding in the joints of a patient with Rheumatoid Arthritis?

  1. Thinning of the synovium and loss of lubrication
  2. Pannus formation with chronic synovial hyperplasia
  3. Urate crystal deposition with giant cell reaction
  4. Extensive subchondral bone cysts without inflammation
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Correct answer: Pannus formation with chronic synovial hyperplasia

Rheumatoid Arthritis involves a chronic proliferative synovitis. A 'pannus' is a mass of edematous synovium, inflammatory cells, granulation tissue, and fibroblasts that erodes the underlying articular cartilage.

Difficulty: Medium Question 10 of 20

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