Patients with which of the following HLA alleles have a significantly higher risk of developing Ankylosing Spondylitis?
Show answer and explanation
Correct answer: HLA-B27
The association between HLA-B27 and Ankylosing Spondylitis is one of the strongest known HLA-disease links. Approximately 90% of affected individuals carry this allele compared to less than 10% of the general population.
Keep practicing
More Autoimmune Diseases questions
- What is the characteristic histological finding in the joints of a patient with Rheumatoid Arthritis?
- Which antibody is most specific for the diagnosis of Rheumatoid Arthritis?
- In Hashimoto thyroiditis, what is the primary cause of follicular cell destruction?
- Which of the following is a hallmark of 'Mixed Connective Tissue Disease' (MCTD)?
- Which autoimmune disease is associated with 'heliotrope rash' and 'Gottron papules'?
- Anti-Jo-1 antibodies are most commonly found in patients with which condition?