In Sjogren syndrome, the immune-mediated destruction primarily targets which of the following tissues?
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Correct answer: Lacrimal and salivary glands
Sjogren syndrome is a chronic disease characterized by lymphocytic infiltration (mainly CD4+ T-cells) of exocrine glands. This leads to the classic symptoms of dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia).
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