Systemic Sclerosis (Scleroderma) is characterized by excessive fibrosis. Which cytokine is considered a major mediator of this fibrotic response?
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Correct answer: TGF-β
TGF-beta is a potent profibrotic cytokine that stimulates the synthesis of collagen and other extracellular matrix proteins by fibroblasts. Its overproduction is central to the skin and visceral thickening seen in scleroderma.
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