In Hashimoto thyroiditis, what is the primary cause of follicular cell destruction?
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Correct answer: CD8+ T-cell killing and ADCC via anti-thyroid antibodies
Hashimoto thyroiditis involves a breakdown in self-tolerance to thyroid autoantigens. Destruction is mediated by cytotoxic T-cells, cytokines from Th1 cells, and the binding of antithyroid antibodies followed by ADCC.
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