Fixatives · Pathology

Zenker's fluid contains which chemical that necessitates thorough washing in water post-fixation to prevent 'chrome pigment'?

  1. Potassium dichromate
  2. Sodium chloride solution
  3. Glutaraldehyde fixative
  4. Denatured methanol
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Correct answer: Potassium dichromate

Zenker's and Helly's fluids contain potassium dichromate. If the tissue is transferred directly to alcohol without washing in water, an insoluble black 'chrome pigment' can form.

Difficulty: Medium Question 11 of 20

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