Fixatives Practice Questions
20 free Fixatives practice questions for the Pathology, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.
Questions
20 questions
All Fixatives questions
- Q1. What is the primary mechanism of action of formaldehyde as a fixative?
- Q2. Which of the following fixatives is considered the 'gold standard' for routine histopathology and long-term storage?
- Q3. A pathology resident observes a brown, granular pigment in a blood-rich tissue section fixed in unbuffered formalin. This pigment can be removed by treating th…
- Q4. Which fixative is specifically preferred for electron microscopy due to its superior preservation of intracellular ultrastructure?
- Q5. Which of the following is a major disadvantage of using Mercuric Chloride-based fixatives (e.g., B5 or Zenker's)?
- Q6. Bouin's fluid is composed of formaldehyde, acetic acid, and which other chemical?
- Q7. What is the primary role of Acetic Acid when included in compound fixatives?
- Q8. Which fixative is the best choice for preserving glycogen and nucleic acids, despite causing significant shrinkage?
- Q9. What is the recommended duration for fixing a 4mm thick tissue specimen in 10% formalin for routine processing?
- Q10. Which of the following fixatives is recommended for fixing lymph nodes to enhance nuclear detail for lymphoma diagnosis?
- Q11. Zenker's fluid contains which chemical that necessitates thorough washing in water post-fixation to prevent 'chrome pigment'?
- Q12. Which fixative is used both as a primary fixative for lipids and a secondary 'stain' for electron microscopy?
- Q13. Acetone is most commonly used as a fixative for:
- Q14. Which of the following describes 'Orth's fluid'?
- Q15. What is the primary drawback of using simple alcohol (Ethanol/Methanol) as a primary fixative for surgical specimens?
- Q16. Which factor significantly accelerates the rate of fixation but may also increase autolysis if not controlled?
- Q17. A fixative that does not chemically combine with the tissue but instead creates an insoluble meshwork of proteins is termed:
- Q18. Michel’s medium is used for:
- Q19. Which of the following fixatives must be avoided if the tissue is to be used for Gömöri methenamine silver (GMS) staining for fungi?
- Q20. What is 'fixation by parchedness' or 'heat fixation' primarily used for in pathology?