A fixative that does not chemically combine with the tissue but instead creates an insoluble meshwork of proteins is termed:
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Correct answer: Coagulant
Coagulant fixatives (like ethanol and picric acid) produce a permeable, mesh-like protein network. Non-coagulant fixatives (like formalin) transform the cytoplasm into a gel, which can make subsequent reagent penetration more difficult.
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