The loss of glycogen from hepatocytes in a tissue section is most commonly an artifact of:
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Correct answer: Aqueous fixation
Glycogen is water-soluble; therefore, fixation in aqueous-based fixatives like formalin can cause its dissolution and loss. To preserve glycogen, non-aqueous fixatives like Carnoy's fluid are preferred.
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More Histological Artifacts questions
- What is the cause of 'out-of-focus' areas when viewing a slide that otherwise seems well-prepared?
- Which artifact is characterized by a blue haze or 'smudging' of the nuclear detail?
- Folds or wrinkles in a tissue section that cannot be removed on the water bath are often due to:
- Which of the following is a common 'contaminant artifact' seen as refractile, jagged crystals?
- The 'hole' seen in the middle of a tissue section after it is placed on a slide is often caused by:
- During H&E staining, if the nuclei appear brown instead of blue, the most likely cause is: