Pharmacology

Cardiovascular pharmacology Practice Questions

20 free Cardiovascular pharmacology practice questions for the USMLE Step 1, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.

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Questions

All Cardiovascular pharmacology questions

20 questions
  1. Q1. Which drug class lowers blood pressure primarily by inhibiting the conversion of angiotensin I to angiotensin II and increasing bradykinin levels?
  2. Q2. Which antihypertensive drug reduces cardiac output by blocking β₁-adrenergic receptors, thereby decreasing heart rate and contractility?
  3. Q3. Which class of antihypertensive drugs works by blocking L-type calcium channels in vascular smooth muscle to reduce peripheral resistance?
  4. Q4. Which diuretic acts on the distal convoluted tubule by inhibiting the Na⁺/Cl⁻ cotransporter, leading to lowered blood pressure?
  5. Q5. Why are angiotensin II receptor blockers (ARBs) sometimes used instead of ACE inhibitors?
  6. Q6. A patient with essential hypertension and osteoporosis may benefit from which antihypertensive drug due to favorable bone effects?
  7. Q7. Which antihypertensive class typically causes ankle edema and headache due to arteriolar dilation?
  8. Q8. Which medication would be most appropriate for acute hypertensive emergency requiring rapid vasodilation?
  9. Q9. Why might a β-blocker worsen asthma symptoms in a patient with reactive airway disease?
  10. Q10. Which antihypertensive drug can trigger a persistent dry cough as a side effect?
  11. Q11. A patient with hypertension and benign prostatic hyperplasia (BPH) may benefit from which antihypertensive class because it improves urinary symptoms?
  12. Q12. Which antihypertensive mechanism acts by reducing circulating blood volume through increased sodium and water excretion?
  13. Q13. A patient with hypertension and type 2 diabetes is started on losartan. Which additional benefit besides BP reduction does losartan provide?
  14. Q14. Which calcium channel blocker class predominantly affects vascular smooth muscle rather than cardiac conduction and contractility?
  15. Q15. Which statement about combining a thiazide diuretic with a β-blocker is correct?
  16. Q16. Which antihypertensive agent is contraindicated in pregnancy because of teratogenic risk to the fetus?
  17. Q17. Which antihypertensive drug class works in part by reducing aldosterone-mediated sodium and water retention?
  18. Q18. A patient with chronic hypertension has difficulty with adherence to multiple medications. Which strategy is often used to improve compliance?
  19. Q19. Which antihypertensive class tends to be more effective at lowering systolic blood pressure in older adults compared to beta-blockers?
  20. Q20. Which antihypertensive treatment would you choose for a patient with high BP and asthma to avoid bronchoconstriction?