Cardiovascular pharmacology · USMLE Step 1

Which statement about combining a thiazide diuretic with a β-blocker is correct?

  1. They act via the same mechanism, so combination is redundant
  2. The diuretic-induced renin increase is blunted by β-blocker
  3. Combination causes severe hyperkalemia
  4. Combination greatly increases heart rate
Show answer and explanation

Correct answer: The diuretic-induced renin increase is blunted by β-blocker

Thiazide diuretics increase renin release via volume reduction; β-blockers blunt this compensatory renin surge, enhancing antihypertensive efficacy.

Difficulty: Medium Question 15 of 20

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