Cardiovascular pharmacology · USMLE Step 1

Why are angiotensin II receptor blockers (ARBs) sometimes used instead of ACE inhibitors?

  1. They raise bradykinin levels much more
  2. They also block L-type calcium channels
  3. They avoid bradykinin-related cough
  4. They directly inhibit renin release
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Correct answer: They avoid bradykinin-related cough

ARBs block angiotensin II’s action at AT₁ receptors without affecting bradykinin breakdown. This reduces risk of ACE inhibitor–related cough and angioedema.

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