Cardiovascular pharmacology · USMLE Step 1

Which antihypertensive drug reduces cardiac output by blocking β₁-adrenergic receptors, thereby decreasing heart rate and contractility?

  1. Losartan
  2. Bisoprolol
  3. Amlodipine
  4. Hydrochlorothiazide
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Correct answer: Bisoprolol

Bisoprolol is a β₁-selective blocker that reduces catecholamine-mediated heart rate and contractility. This lowers cardiac output and blood pressure.

Difficulty: Medium Question 2 of 20

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