Systemic Pathology by Organ · USMLE Step 1

Which morphological change is most typical of long-standing pulmonary emphysema on gross lung examination?

  1. Numerous firm white nodules
  2. Honeycomb cystic spaces predominantly subpleural
  3. Dilated, over-inflated lungs with blebs
  4. Caseating granulomas in upper lobes
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Correct answer: Dilated, over-inflated lungs with blebs

Emphysema causes destruction of alveolar walls, leading to over-inflated lungs and formation of blebs or bullae; grossly the lungs appear hyper-inflated and pale. (Respiratory system pathology)

Difficulty: Medium Question 4 of 19

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