An activating point mutation in a proto-oncogene converts it into an oncogene. What is the usual effect of this change?
Show answer and explanation
Correct answer: Constitutive activation of growth signaling
Oncogenes — mutated or overexpressed proto-oncogenes — drive constitutive activation of growth signals, promoting uncontrolled proliferation even without external growth factors.
Keep practicing
More Neoplasia and Cancer Biology questions
- Which hallmark of cancer reflects a tumor’s ability to stimulate formation of blood vessels to support its growth?
- Which of the following features is characteristic of anaplasia in malignant tumors?
- Which process describes the clonal evolution of neoplastic cells accumulating further mutations over time?
- Which of the following cell-intrinsic capabilities is NOT among the classical hallmarks of cancer as per Hanahan & Weinberg’s original mode…
- The transition from a pre-malignant lesion to invasive cancer typically requires which additional capability acquired by tumor cells?
- Which classification system describes the extent of spread of a malignant tumor including size, lymph node involvement, and metastasis?