Hypersensitivity and Autoimmunity Practice Questions
20 free Hypersensitivity and Autoimmunity practice questions for the USMLE Step 1, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.
Questions
20 questions
All Hypersensitivity and Autoimmunity questions
- Q1. A patient develops hives, bronchospasm, and hypotension minutes after eating peanuts. Which hypersensitivity reaction is this?
- Q2. A newborn develops hemolytic disease of the newborn due to maternal anti-Rh antibodies. Which hypersensitivity mechanism is responsible?
- Q3. A patient with systemic lupus erythematosus develops glomerulonephritis due to circulating immune complexes. This reflects which hypersensitivity type?
- Q4. A patient undergoes a PPD skin test. After 48 hours, a firm erythematous induration appears. Which hypersensitivity type is this?
- Q5. A patient develops hemolytic anemia after receiving penicillin. The drug binds to RBCs, forming a target for antibodies. Which mechanism is involved?
- Q6. A patient experiences serum sickness after receiving antivenom. What causes this reaction?
- Q7. Contact dermatitis due to poison ivy exposure is caused by which immune mechanism?
- Q8. Graves disease involves autoantibodies that stimulate the TSH receptor. Which hypersensitivity type is this?
- Q9. A patient with myasthenia gravis produces antibodies that block acetylcholine receptors. Which hypersensitivity classification fits this?
- Q10. A biopsy from a patient with granulomatous inflammation shows macrophages surrounded by activated T cells. Which hypersensitivity type is implicated?
- Q11. A man develops a rash 10 days after starting a new antibiotic. Immune complex deposition is suspected. Which test helps confirm Type III hypersensitivity?
- Q12. A patient with Hashimoto thyroiditis produces anti-thyroid peroxidase antibodies. What type of immune process underlies this?
- Q13. A blood transfusion reaction involving fever, hypotension, and hemoglobinuria is caused by which mechanism?
- Q14. A patient with rheumatoid arthritis has circulating rheumatoid factor. What does this factor bind?
- Q15. Patients with multiple sclerosis develop demyelination due to autoimmunity. What is the primary mechanism?
- Q16. A patient develops hematuria following a streptococcal infection. Immune complex deposition in glomeruli is seen. What disease is most likely?
- Q17. A patient shows blistering skin lesions in which antibodies target desmoglein. What is the mechanism?
- Q18. A patient develops urticaria after receiving radiocontrast dye. Which mediator is primarily released during this reaction?
- Q19. A patient with celiac disease develops intestinal damage due to T-cell activation against gluten peptides. Which hypersensitivity type is this?
- Q20. A patient with Goodpasture syndrome produces autoantibodies attacking basement membranes. What type of hypersensitivity reaction is involved?