Hypersensitivity and Autoimmunity · USMLE Step 1

Graves disease involves autoantibodies that stimulate the TSH receptor. Which hypersensitivity type is this?

  1. Type I
  2. Type II
  3. Type III
  4. Type IV
Show answer and explanation

Correct answer: Type II

Type II reactions can be cytotoxic or receptor-modulating. Graves disease involves stimulatory IgG binding to TSH receptors.

Difficulty: Medium Question 8 of 20

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