Hypersensitivity and Autoimmunity · USMLE Step 1

A patient with Goodpasture syndrome produces autoantibodies attacking basement membranes. What type of hypersensitivity reaction is involved?

  1. Type I
  2. Type II
  3. Type III
  4. Type IV
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Correct answer: Type II

Goodpasture syndrome is a classic Type II reaction targeting the basement membrane. Complement activation causes lung and kidney injury.

Difficulty: Medium Question 20 of 20

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