Hypersensitivity and Autoimmunity · USMLE Step 1

A patient with celiac disease develops intestinal damage due to T-cell activation against gluten peptides. Which hypersensitivity type is this?

  1. Type I
  2. Type II
  3. Type III
  4. Type IV
Show answer and explanation

Correct answer: Type IV

Celiac disease involves a Type IV T-cell–mediated response to gluten. Chronic inflammation leads to villous atrophy.

Difficulty: Medium Question 19 of 20

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