Cytoskeleton and motility · USMLE Step 1

During mitosis, which cytoskeletal structure is primarily responsible for separating sister chromatids and segregating chromosomes to opposite poles?

  1. Actin filaments forming the contractile ring
  2. Intermediate filaments organizing nuclear lamina
  3. Microtubules forming the mitotic spindle
  4. Desmin intermediate filaments
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Correct answer: Microtubules forming the mitotic spindle

Microtubules reorganize into the mitotic spindle that attaches to chromosomes and pulls sister chromatids to opposite poles during cell division.

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