Cytoskeleton and motility · USMLE Step 1

What is the role of actin polymerization at the leading edge of a migrating cell?

  1. Microtubules
  2. Actin microfilaments
  3. Intermediate filaments
  4. Centrosomes
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Correct answer: Intermediate filaments

Polymerization of actin filaments at the leading edge causes expansion of the actin network, pushing the plasma membrane outward and forming structures such as lamellipodia and filopodia needed for cell movement.

Difficulty: Medium Question 11 of 21

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