Cell-cell junctions · USMLE Step 1

Which of the following statements about communicating junctions is true?

  1. They use cadherins to link cytoskeletons of neighboring cells.
  2. They block paracellular diffusion of small dissolved molecules.
  3. They form cytoplasmic channels passing ions and small metabolites.
  4. They anchor cells firmly to the surrounding extracellular matrix.
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Correct answer: They form cytoplasmic channels passing ions and small metabolites.

Communicating junctions (gap junctions) consist of channel-forming connexons that directly connect cytoplasm of adjacent cells, allowing passage of ions and small metabolites — facilitating intercellular communication.

Difficulty: Medium Question 18 of 20

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