Cell-cell junctions · USMLE Step 1

Which of the following junction types is LEAST likely to be found between adjacent endothelial cells of a leaky capillary where high permeability is required?

  1. Adherens junctions
  2. Desmosomes
  3. Tight junctions
  4. Gap junctions
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Correct answer: Tight junctions

Tight junctions create tight seals — in leaky capillaries (e.g., certain fenestrated or sinusoidal endothelium) such seals are minimized to allow high permeability; thus tight junctions are reduced or absent in such areas. Anchoring and communicating junctions may still be present.

Difficulty: Medium Question 20 of 20

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