Cell-cell junctions · USMLE Step 1

Which class of cell–cell junctions primarily functions to seal adjacent epithelial cells and prevent paracellular leakage of molecules and ions?

  1. Anchoring junctions
  2. Adherens junctions
  3. Occluding junctions
  4. Gap junctions
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Correct answer: Occluding junctions

Occluding junctions, also known as tight junctions (zonula occludens), seal the plasma membranes of adjacent cells to prevent paracellular passage of water and solutes, maintaining a barrier between compartments.

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