Cell-cell junctions · USMLE Step 1

Which type of cell–cell junction is characterized by direct cytoplasmic connections allowing passage of ions and small molecules between adjacent cells?

  1. Desmosomes
  2. Hemidesmosomes
  3. Tight junctions
  4. Gap junctions
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Correct answer: Gap junctions

Gap junctions are communicating junctions composed of connexon channels that span the membranes of two adjacent cells, enabling direct passage of small molecules and ions between their cytoplasms.

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