Cell-cell junctions · USMLE Step 1

Which of the following junction types links the actin cytoskeleton of one cell to that of its neighbor, providing mechanical support and maintaining tissue integrity?

  1. Hemidesmosome
  2. Adherens junction
  3. Tight junction
  4. Gap junction
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Correct answer: Adherens junction

Adherens junctions (zonula adherens) use cadherin transmembrane proteins and intracellular catenins to link the actin cytoskeleton across neighboring epithelial cells, thereby contributing to mechanical cohesion and shape maintenance.

Difficulty: Medium Question 5 of 20

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